The Irrationality of GOF Avian Influenza Virus Research
Identifieur interne : 000110 ( France/Analysis ); précédent : 000109; suivant : 000111The Irrationality of GOF Avian Influenza Virus Research
Auteurs : Simon Wain-Hobson [France, États-Unis]Source :
- Frontiers in Public Health [ 2296-2565 ] ; 2014.
Abstract
The last two and a half years have witnessed a curious debate in virology characterized by a remarkable lack of discussion. It goes by the misleading epithet “gain of function” (GOF) influenza virus research, or simply GOF. As will be seen, there is nothing good to be gained. The controversial experiments confer aerosol transmission on avian influenza virus strains that can infect humans, but which are not naturally transmitted between humans. Some of the newer strains are clearly highly pathogenic for man. It will be shown here that the benefits of the work are erroneous and overstated while the risk of an accident is finite, if small. The consequence of any accident would be anywhere from a handful of infections to a catastrophic pandemic. There has been a single open international meeting in this period, which is surprising given that openness and discussion are essential to good science. Despite US and EU government funding, no risk–benefit analysis has been published, which again is surprising. This research can be duplicated readily in many labs and requires little high tech. It falls under the definition of DURC without the slightest shadow of a doubt and constitutes the most important challenge facing contemporary biology.
Url:
DOI: 10.3389/fpubh.2014.00077
PubMed: 25077136
PubMed Central: 4099557
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D63
- to stream Pmc, to step Curation: 000D63
- to stream Pmc, to step Checkpoint: 000445
- to stream Ncbi, to step Merge: 000A67
- to stream Ncbi, to step Curation: 000A67
- to stream Ncbi, to step Checkpoint: 000A67
- to stream Main, to step Merge: 000659
- to stream Main, to step Curation: 000658
- to stream Main, to step Exploration: 000658
- to stream France, to step Extraction: 000110
Links to Exploration step
PMC:4099557Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Irrationality of GOF Avian Influenza Virus Research</title><author><name sortKey="Wain Hobson, Simon" sort="Wain Hobson, Simon" uniqKey="Wain Hobson S" first="Simon" last="Wain-Hobson">Simon Wain-Hobson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Molecular Retrovirology Unit, Department of Virology, Institut Pasteur</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Foundation for Vaccine Research</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25077136</idno><idno type="pmc">4099557</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099557</idno><idno type="RBID">PMC:4099557</idno><idno type="doi">10.3389/fpubh.2014.00077</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000D63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D63</idno><idno type="wicri:Area/Pmc/Curation">000D63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D63</idno><idno type="wicri:Area/Pmc/Checkpoint">000445</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000445</idno><idno type="wicri:Area/Ncbi/Merge">000A67</idno><idno type="wicri:Area/Ncbi/Curation">000A67</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A67</idno><idno type="wicri:Area/Main/Merge">000659</idno><idno type="wicri:Area/Main/Curation">000658</idno><idno type="wicri:Area/Main/Exploration">000658</idno><idno type="wicri:Area/France/Extraction">000110</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Irrationality of GOF Avian Influenza Virus Research</title><author><name sortKey="Wain Hobson, Simon" sort="Wain Hobson, Simon" uniqKey="Wain Hobson S" first="Simon" last="Wain-Hobson">Simon Wain-Hobson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Molecular Retrovirology Unit, Department of Virology, Institut Pasteur</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Foundation for Vaccine Research</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Public Health</title><idno type="eISSN">2296-2565</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The last two and a half years have witnessed a curious debate in virology characterized by a remarkable lack of discussion. It goes by the misleading epithet “gain of function” (GOF) influenza virus research, or simply GOF. As will be seen, there is nothing good to be gained. The controversial experiments confer aerosol transmission on avian influenza virus strains that can infect humans, but which are not naturally transmitted between humans. Some of the newer strains are clearly highly pathogenic for man. It will be shown here that the benefits of the work are erroneous and overstated while the risk of an accident is finite, if small. The consequence of any accident would be anywhere from a handful of infections to a catastrophic pandemic. There has been a single open international meeting in this period, which is surprising given that openness and discussion are essential to good science. Despite US and EU government funding, no risk–benefit analysis has been published, which again is surprising. This research can be duplicated readily in many labs and requires little high tech. It falls under the definition of DURC without the slightest shadow of a doubt and constitutes the most important challenge facing contemporary biology.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Imai, M" uniqKey="Imai M">M Imai</name></author><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name></author><author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name></author><author><name sortKey="Das, Sc" uniqKey="Das S">SC Das</name></author><author><name sortKey="Ozawa, M" uniqKey="Ozawa M">M Ozawa</name></author><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name></author><author><name sortKey="Schrauwen, Ej" uniqKey="Schrauwen E">EJ Schrauwen</name></author><author><name sortKey="Linster, M" uniqKey="Linster M">M Linster</name></author><author><name sortKey="Chutinimitkul, S" uniqKey="Chutinimitkul S">S Chutinimitkul</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Kong, H" uniqKey="Kong H">H Kong</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sutton, Tc" uniqKey="Sutton T">TC Sutton</name></author><author><name sortKey="Finch, C" uniqKey="Finch C">C Finch</name></author><author><name sortKey="Shao, H" uniqKey="Shao H">H Shao</name></author><author><name sortKey="Angel, M" uniqKey="Angel M">M Angel</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Capua, I" uniqKey="Capua I">I Capua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wain Hobson, S" uniqKey="Wain Hobson S">S Wain-Hobson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furmanski, M" uniqKey="Furmanski M">M Furmanski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="York, I" uniqKey="York I">I York</name></author><author><name sortKey="Donis, Ro" uniqKey="Donis R">RO Donis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morse, Ss" uniqKey="Morse S">SS Morse</name></author><author><name sortKey="Mazet, Ja" uniqKey="Mazet J">JA Mazet</name></author><author><name sortKey="Woolhouse, M" uniqKey="Woolhouse M">M Woolhouse</name></author><author><name sortKey="Parrish, Cr" uniqKey="Parrish C">CR Parrish</name></author><author><name sortKey="Carroll, D" uniqKey="Carroll D">D Carroll</name></author><author><name sortKey="Karesh, Wb" uniqKey="Karesh W">WB Karesh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wain Hobson, S" uniqKey="Wain Hobson S">S Wain-Hobson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, R" uniqKey="Gao R">R Gao</name></author><author><name sortKey="Cao, B" uniqKey="Cao B">B Cao</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Hu, W" uniqKey="Hu W">W Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shortridge, Kf" uniqKey="Shortridge K">KF Shortridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name></author><author><name sortKey="Yen, Hl" uniqKey="Yen H">HL Yen</name></author><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epperson, S" uniqKey="Epperson S">S Epperson</name></author><author><name sortKey="Blanton, L" uniqKey="Blanton L">L Blanton</name></author><author><name sortKey="Kniss, K" uniqKey="Kniss K">K Kniss</name></author><author><name sortKey="Mustaquim, D" uniqKey="Mustaquim D">D Mustaquim</name></author><author><name sortKey="Steffens, C" uniqKey="Steffens C">C Steffens</name></author><author><name sortKey="Wallis, T" uniqKey="Wallis T">T Wallis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Yuan, H" uniqKey="Yuan H">H Yuan</name></author><author><name sortKey="Gao, R" uniqKey="Gao R">R Gao</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Xiong, Y" uniqKey="Xiong Y">Y Xiong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name></author><author><name sortKey="Schmolke, M" uniqKey="Schmolke M">M Schmolke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parry, J" uniqKey="Parry J">J Parry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Tsang, Ak" uniqKey="Tsang A">AK Tsang</name></author><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tharakaraman, K" uniqKey="Tharakaraman K">K Tharakaraman</name></author><author><name sortKey="Raman, R" uniqKey="Raman R">R Raman</name></author><author><name sortKey="Viswanathan, K" uniqKey="Viswanathan K">K Viswanathan</name></author><author><name sortKey="Stebbins, Nw" uniqKey="Stebbins N">NW Stebbins</name></author><author><name sortKey="Jayaraman, A" uniqKey="Jayaraman A">A Jayaraman</name></author><author><name sortKey="Krishnan, A" uniqKey="Krishnan A">A Krishnan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, J" uniqKey="Yuan J">J Yuan</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Kan, X" uniqKey="Kan X">X Kan</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Guo, Z" uniqKey="Guo Z">Z Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Noorden, R" uniqKey="Van Noorden R">R Van Noorden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name></author><author><name sortKey="Plotkin, Jb" uniqKey="Plotkin J">JB Plotkin</name></author><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name></author><author><name sortKey="Bloom, B" uniqKey="Bloom B">B Bloom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterholm, Mt" uniqKey="Osterholm M">MT Osterholm</name></author><author><name sortKey="Relman, Da" uniqKey="Relman D">DA Relman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country></list><tree><country name="France"><noRegion><name sortKey="Wain Hobson, Simon" sort="Wain Hobson, Simon" uniqKey="Wain Hobson S" first="Simon" last="Wain-Hobson">Simon Wain-Hobson</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Wain Hobson, Simon" sort="Wain Hobson, Simon" uniqKey="Wain Hobson S" first="Simon" last="Wain-Hobson">Simon Wain-Hobson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000110 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000110 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= France
|étape= Analysis
|type= RBID
|clé= PMC:4099557
|texte= The Irrationality of GOF Avian Influenza Virus Research
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:25077136" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |